PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

Inhibitory signals through the PD-1 pathway regulate T cell activation, T cell tolerance, and T cell exhaustion. Studies of PD-1 function have focused primarily on effector T cells. Far less is known about PD-1 function in regulatory T (T reg) cells. To study the role of PD-1 in T reg cells, we gene...

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Publicado no:J Exp Med
Main Authors: Tan, Catherine L., Kuchroo, Juhi R., Sage, Peter T., Liang, Dan, Francisco, Loise M., Buck, Jessica, Thaker, Youg Raj, Zhang, Qianxia, McArdel, Shannon L., Juneja, Vikram R., Lee, Sun Jung, Lovitch, Scott B., Lian, Christine, Murphy, George F., Blazar, Bruce R., Vignali, Dario A.A., Freeman, Gordon J., Sharpe, Arlene H.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543091/
https://ncbi.nlm.nih.gov/pubmed/33045061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182232
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