AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation

Despite being the frontline therapy for type 2 diabetes, the mechanisms of action of the biguanide drug metformin are still being discovered. In particular, the detailed molecular interplays between the AMPK and the mTORC1 pathway in the hepatic benefits of metformin are still ill defined. Metformin...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Van Nostrand, Jeanine L., Hellberg, Kristina, Luo, En-Ching, Van Nostrand, Eric L., Dayn, Alina, Yu, Jingting, Shokhirev, Maxim N., Dayn, Yelena, Yeo, Gene W., Shaw, Reuben J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2020
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7528705/
https://ncbi.nlm.nih.gov/pubmed/32912901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.339895.120
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