AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation

Despite being the frontline therapy for type 2 diabetes, the mechanisms of action of the biguanide drug metformin are still being discovered. In particular, the detailed molecular interplays between the AMPK and the mTORC1 pathway in the hepatic benefits of metformin are still ill defined. Metformin...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Van Nostrand, Jeanine L., Hellberg, Kristina, Luo, En-Ching, Van Nostrand, Eric L., Dayn, Alina, Yu, Jingting, Shokhirev, Maxim N., Dayn, Yelena, Yeo, Gene W., Shaw, Reuben J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7528705/
https://ncbi.nlm.nih.gov/pubmed/32912901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.339895.120
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