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Metformin inhibits hepatic mTORC1 signaling via dose-dependent mechanisms involving AMPK and the TSC complex

Metformin is the most widely prescribed drug for the treatment of type-2 diabetes. However, knowledge of the full effects of metformin on biochemical pathways and processes in its primary target tissue, the liver, is limited. One established effect of metformin is to decrease cellular energy levels....

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Howell, Jessica J., Hellberg, Kristina, Turner, Marc, Talbott, George, Kolar, Matthew J., Ross, Debbie Vasquez, Hoxhaj, Gerta, Saghatelian, Alan, Shaw, Reuben J., Manning, Brendan D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299044/
https://ncbi.nlm.nih.gov/pubmed/28089566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.12.009
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