The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth

Summary: The tuberous sclerosis complex (TSC) 1 and 2 proteins associate with TBC1D7 to form the TSC complex, which is an essential suppressor of mTOR complex 1 (mTORC1), a ubiquitous driver of cell and tissue growth. Loss-of-function mutations in TSC1 or TSC2, but not TBC1D7, give rise to TSC, a pl...

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Main Authors: Sandra Schrötter, Christopher J. Yuskaitis, Michael R. MacArthur, Sarah J. Mitchell, Aaron M. Hosios, Maria Osipovich, Margaret E. Torrence, James R. Mitchell, Gerta Hoxhaj, Mustafa Sahin, Brendan D. Manning
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-05-01
Colecção:Cell Reports
Assuntos:
CP: Developmental biology
CP: Neuroscience
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124722005952
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