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AMPK phosphorylation of raptor mediates a metabolic checkpoint
AMPK is a highly conserved sensor of cellular energy status that is activated under conditions of low intracellular ATP. AMPK responds to energy stress by suppressing cell growth and biosynthetic processes, in part through its inhibition of the rapamycin-sensitive mTOR (mTORC1) pathway. AMPK phospho...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2674027/ https://ncbi.nlm.nih.gov/pubmed/18439900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.03.003 |
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