AMPK phosphorylation of raptor mediates a metabolic checkpoint

AMPK is a highly conserved sensor of cellular energy status that is activated under conditions of low intracellular ATP. AMPK responds to energy stress by suppressing cell growth and biosynthetic processes, in part through its inhibition of the rapamycin-sensitive mTOR (mTORC1) pathway. AMPK phospho...

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Main Authors: Gwinn, Dana M., Shackelford, David B., Egan, Daniel F., Mihaylova, Maria M., Mery, Annabelle, Vasquez, Debbie S., Turk, Benjamin E., Shaw, Reuben J.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674027/
https://ncbi.nlm.nih.gov/pubmed/18439900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.03.003
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