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The LKB1-AMPK pathway: metabolism and growth control in tumor suppression
In the past decade, studies of the human tumor suppressor LKB1 have uncovered a novel signaling pathway that links cell metabolism to growth control and cell polarity. LKB1 encodes a serine/threonine kinase that directly phosphorylates and activates AMPK, a central metabolic sensor. AMPK regulates l...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2756045/ https://ncbi.nlm.nih.gov/pubmed/19629071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc2676 |
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