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An Lkb1-Sik axis suppresses lung tumor growth and controls differentiation

The kinase, LKB1, is a critical tumor suppressor in sporadic and familial human cancers, yet the mechanisms by which it suppresses tumor growth remain poorly understood. To investigate the tumor-suppressive capacity of four canonical families of Lkb1 substrates in vivo, we employed CRISPR/Cas9-media...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Murray, Christopher W., Brady, Jennifer J., Tsai, Min K., Li, Chuan, Winters, Ian P., Tang, Rui, Andrejka, Laura, Ma, Rosanna K., Kunder, Christian A., Chu, Pauline, Winslow, Monte M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825558/
https://ncbi.nlm.nih.gov/pubmed/31350327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1237
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