The AMPK-related kinases SIK1 and SIK3 mediate key tumor suppressive effects of LKB1 in NSCLC.

Mutations in the LKB1 (STK11) tumor suppressor are the third most frequent genetic alteration in non-small-cell lung cancer (NSCLC). LKB1 encodes a serine/threonine kinase that directly phosphorylates and activates 14 AMPK family kinases (“AMPKRs”). The function of many of the AMPKRs remains obscure...

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Pubblicato in:Cancer Discov
Autori principali: Hollstein, Pablo E., Eichner, Lillian J., Brun, Sonja N., Kamireddy, Anwesh, Svensson, Robert U., Vera, Liliana I., Ross, Debbie S., Rymoff, T.J., Hutchins, Amanda, Galvez, Hector M., Williams, April E., Shokhirev, Maxim N., Screaton, Robert A., Berdeaux, Rebecca, Shaw, Reuben J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825547/
https://ncbi.nlm.nih.gov/pubmed/31350328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1261
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