The AMPK-related kinases SIK1 and SIK3 mediate key tumor suppressive effects of LKB1 in NSCLC.

Mutations in the LKB1 (STK11) tumor suppressor are the third most frequent genetic alteration in non-small-cell lung cancer (NSCLC). LKB1 encodes a serine/threonine kinase that directly phosphorylates and activates 14 AMPK family kinases (“AMPKRs”). The function of many of the AMPKRs remains obscure...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cancer Discov
Autors principals: Hollstein, Pablo E., Eichner, Lillian J., Brun, Sonja N., Kamireddy, Anwesh, Svensson, Robert U., Vera, Liliana I., Ross, Debbie S., Rymoff, T.J., Hutchins, Amanda, Galvez, Hector M., Williams, April E., Shokhirev, Maxim N., Screaton, Robert A., Berdeaux, Rebecca, Shaw, Reuben J.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825547/
https://ncbi.nlm.nih.gov/pubmed/31350328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1261
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars