The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non–small cell lung cancer

The LKB1 tumor suppressor is often mutationally inactivated in non–small cell lung cancer (NSCLC). LKB1 phosphorylates and activates members of the AMPK family of Ser/Thr kinases. Within this family, the salt-inducible kinases (SIKs) modulate gene expression in part via the inhibitory phosphorylatio...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Rodón, Laura, Svensson, Robert U., Wiater, Ezra, Chun, Matthew G. H, Tsai, Wen-Wei, Eichner, Lillian J., Shaw, Reuben J., Montminy, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656544/
https://ncbi.nlm.nih.gov/pubmed/31355336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw6455
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados