The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non–small cell lung cancer

The LKB1 tumor suppressor is often mutationally inactivated in non–small cell lung cancer (NSCLC). LKB1 phosphorylates and activates members of the AMPK family of Ser/Thr kinases. Within this family, the salt-inducible kinases (SIKs) modulate gene expression in part via the inhibitory phosphorylatio...

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Библиографические подробности
Опубликовано в: :Sci Adv
Главные авторы: Rodón, Laura, Svensson, Robert U., Wiater, Ezra, Chun, Matthew G. H, Tsai, Wen-Wei, Eichner, Lillian J., Shaw, Reuben J., Montminy, Marc
Формат: Artigo
Язык:Inglês
Опубликовано: American Association for the Advancement of Science 2019
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656544/
https://ncbi.nlm.nih.gov/pubmed/31355336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw6455
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