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The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non–small cell lung cancer
The LKB1 tumor suppressor is often mutationally inactivated in non–small cell lung cancer (NSCLC). LKB1 phosphorylates and activates members of the AMPK family of Ser/Thr kinases. Within this family, the salt-inducible kinases (SIKs) modulate gene expression in part via the inhibitory phosphorylatio...
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| 出版年: | Sci Adv |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Association for the Advancement of Science
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6656544/ https://ncbi.nlm.nih.gov/pubmed/31355336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw6455 |
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