Genetic analysis reveals AMPK is required to support tumor growth in murine Kras-dependent lung cancer models

AMPK, a conserved sensor of low cellular energy. can either repress or promote tumor growth depending on the context. However, no studies have examined AMPK function in autochthonous genetic mouse models of epithelial cancer. Here, we examine the role of AMPK in murine Kras(G12D) mediated non-small...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Metab
Egile Nagusiak: Eichner, Lillian J., Brun, Sonja N., Herzig, Sébastien, Young, Nathan P., Curtis, Stephanie D., Shackelford, David B., Shokhirev, Maxim N., Leblanc, Mathias, Vera, Liliana I., Hutchins, Amanda, Ross, Debbie S., Shaw, Reuben J., Svensson, Robert U.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365213/
https://ncbi.nlm.nih.gov/pubmed/30415923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.10.005
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