Genetic analysis reveals AMPK is required to support tumor growth in murine Kras-dependent lung cancer models

AMPK, a conserved sensor of low cellular energy. can either repress or promote tumor growth depending on the context. However, no studies have examined AMPK function in autochthonous genetic mouse models of epithelial cancer. Here, we examine the role of AMPK in murine Kras(G12D) mediated non-small...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Eichner, Lillian J., Brun, Sonja N., Herzig, Sébastien, Young, Nathan P., Curtis, Stephanie D., Shackelford, David B., Shokhirev, Maxim N., Leblanc, Mathias, Vera, Liliana I., Hutchins, Amanda, Ross, Debbie S., Shaw, Reuben J., Svensson, Robert U.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365213/
https://ncbi.nlm.nih.gov/pubmed/30415923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.10.005
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