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An Lkb1-Sik axis suppresses lung tumor growth and controls differentiation
The kinase, LKB1, is a critical tumor suppressor in sporadic and familial human cancers, yet the mechanisms by which it suppresses tumor growth remain poorly understood. To investigate the tumor-suppressive capacity of four canonical families of Lkb1 substrates in vivo, we employed CRISPR/Cas9-media...
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| Vydáno v: | Cancer Discov |
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| Hlavní autoři: | , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6825558/ https://ncbi.nlm.nih.gov/pubmed/31350327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1237 |
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