Fragment-based drug discovery: opportunities for organic synthesis

di St. Denis, Jeffrey D., Hall, Richard J., Murray, Christopher W., Heightman, Tom D., Rees, David C.
Pubblicato in RSC Med Chem (2020)

Associations between Patient Global Assessment scores and pain, physical function, and fatigue in rheumatoid arthritis: a post hoc analysis of data from phase 3 trials of tofacitin...

di Strand, Vibeke, Kaine, Jeffrey, Alten, Rieke, Wallenstein, Gene, Diehl, Annette, Shi, Harry, Germino, Rebecca, Murray, Christopher W.
Pubblicato in Arthritis Res Ther (2020)

Validity of Ligand Efficiency Metrics

di Murray, Christopher W., Erlanson, Daniel A., Hopkins, Andrew L., Keserü, György M., Leeson, Paul D., Rees, David C., Reynolds, Charles H., Richmond, Nicola J.
Pubblicazione 2014

An Lkb1-Sik axis suppresses lung tumor growth and controls differentiation

di Murray, Christopher W., Brady, Jennifer J., Tsai, Min K., Li, Chuan, Winters, Ian P., Tang, Rui, Andrejka, Laura, Ma, Rosanna K., Kunder, Christian A., Chu, Pauline, Winslow, Monte M.
Pubblicato in Cancer Discov (2019)

A versatile system to record cell-cell interactions

di Tang, Rui, Murray, Christopher W, Linde, Ian L, Kramer, Nicholas J, Lyu, Zhonglin, Tsai, Min K, Chen, Leo C, Cai, Hongchen, Gitler, Aaron D, Engleman, Edgar, Lee, Wonjae, Winslow, Monte M
Pubblicato in eLife (2020)

An Arntl2-driven secretome enables lung adenocarcinoma metastatic self-sufficiency

di Brady, Jennifer J., Chuang, Chen-Hua, Greenside, Peyton G., Rogers, Zoë N., Murray, Christopher W., Caswell, Deborah R., Hartmann, Ursula, Connolly, Andrew J., Sweet-Cordero, E. Alejandro, Kundaje, Anshul, Winslow, Monte M.
Pubblicato in Cancer Cell (2016)

Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket

di Saalau-Bethell, Susanne M, Berdini, Valerio, Cleasby, Anne, Congreve, Miles, Coyle, Joseph E, Lock, Victoria, Murray, Christopher W, O'Brien, M Alistair, Rich, Sharna J, Sambrook, Tracey, Vinkovic, Mladen, Yon, Jeff R, Jhoti, Harren
Pubblicato in ChemMedChem (2014)

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

di Saalau-Bethell, Susanne M., Woodhead, Andrew J., Chessari, Gianni, Carr, Maria G., Coyle, Joseph, Graham, Brent, Hiscock, Steven D., Murray, Christopher W., Pathuri, Puja, Rich, Sharna J., Richardson, Caroline J., Williams, Pamela A., Jhoti, Harren
Pubblicazione 2012

Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors

di Murray, Christopher W., Berdini, Valerio, Buck, Ildiko M., Carr, Maria E., Cleasby, Anne, Coyle, Joseph E., Curry, Jayne E., Day, James E. H., Day, Phillip J., Hearn, Keisha, Iqbal, Aman, Lee, Lydia Y. W., Martins, Vanessa, Mortenson, Paul N., Munck, Joanne M., Page, Lee W., Patel, Sahil, Roomans, Susan, Smith, Kirsten, Tamanini, Emiliano, Saxty, Gordon
Pubblicato in ACS Med Chem Lett (2015)

A functional taxonomy of tumor suppression in oncogenic KRAS-driven lung cancer

di Cai, Hongchen, Chew, Su Kit, Li, Chuan, Tsai, Min K., Andrejka, Laura, Murray, Christopher W., Hughes, Nicholas W., Shuldiner, Emily G., Ashkin, Emily L., Tang, Rui, Hung, King L., Chen, Leo C., Lee, Shi Ya C., Yousefi, Maryam, Lin, Wen-Yang, Kunder, Christian A., Cong, Le, McFarland, Christopher D., Petrov, Dmitri A., Swanton, Charles, Winslow, Monte M.
Pubblicato in Cancer Discov (2021)

The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D

di Chaikovsky, Andrea C., Li, Chuan, Jeng, Edwin E., Loebell, Samuel, Lee, Myung Chang, Murray, Christopher W., Cheng, Ran, Demeter, Janos, Swaney, Danielle L., Chen, Si-Han, Newton, Billy W., Johnson, Jeffrey R., Drainas, Alexandros P., Shue, Yan Ting, Seoane, Jose A., Srinivasan, Preethi, He, Andy, Yoshida, Akihiro, Hipkins, Susan Q., McCrea, Edel, Poltorack, Carson D., Krogan, Nevan J., Diehl, J. Alan, Kong, Christina, Jackson, Peter K., Curtis, Christina, Petrov, Dmitri A., Bassik, Michael C., Winslow, Monte M., Sage, Julien
Pubblicato in Nature (2021)