Validity of Ligand Efficiency Metrics

A recent viewpoint article (Improving the plausibility of success with inefficient metrics. ACS Med. Chem. Lett.2014, 5, 2–5) argued that the standard definition of ligand efficiency (LE) is mathematically invalid. In this viewpoint, we address this criticism and show categorically that the definiti...

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Bibliographic Details
Main Authors: Murray, Christopher W., Erlanson, Daniel A., Hopkins, Andrew L., Keserü, György M., Leeson, Paul D., Rees, David C., Reynolds, Charles H., Richmond, Nicola J.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060940/
https://ncbi.nlm.nih.gov/pubmed/24944729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500146d
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