Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Here we report the discovery of a highly conserved novel binding site located at the interface between the protease and helicase domains of the Hepatitis C Virus (HCV) NS3 protein. Using a chemical lead, identified by fragment screening and structure-guided design, we demonstrate that this site has...

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Main Authors: Saalau-Bethell, Susanne M., Woodhead, Andrew J., Chessari, Gianni, Carr, Maria G., Coyle, Joseph, Graham, Brent, Hiscock, Steven D., Murray, Christopher W., Pathuri, Puja, Rich, Sharna J., Richardson, Caroline J., Williams, Pamela A., Jhoti, Harren
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480716/
https://ncbi.nlm.nih.gov/pubmed/23023261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1081
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