Protease Inhibitors Block Multiple Functions of the NS3/4A Protease-Helicase during the Hepatitis C Virus Life Cycle

Hepatitis C virus (HCV) NS3 is a multifunctional protein composed of a protease domain and a helicase domain linked by a flexible linker. Protease activity is required to generate viral nonstructural (NS) proteins involved in RNA replication. Helicase activity is required for RNA replication, and ge...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Virol
Main Authors: McGivern, David R., Masaki, Takahiro, Lovell, William, Hamlett, Chris, Saalau-Bethell, Susanne, Graham, Brent
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442512/
https://ncbi.nlm.nih.gov/pubmed/25740995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03188-14
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