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The LKB1-AMPK pathway: metabolism and growth control in tumor suppression

In the past decade, studies of the human tumor suppressor LKB1 have uncovered a novel signaling pathway that links cell metabolism to growth control and cell polarity. LKB1 encodes a serine/threonine kinase that directly phosphorylates and activates AMPK, a central metabolic sensor. AMPK regulates l...

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Dades bibliogràfiques
Autors principals: Shackelford, David B., Shaw, Reuben J.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756045/
https://ncbi.nlm.nih.gov/pubmed/19629071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc2676
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