Metformin effectively treats Tsc1 deletion-caused kidney pathology by upregulating AMPK phosphorylation

Tuberous sclerosis complex (TSC) is characterized by hamartomatous lesions in multiple organs, with most patients developing polycystic kidney disease and leading to a decline of renal function. TSC is caused by loss-of-function mutations in either Tsc1 or Tsc2 gene, but currently, there is no effec...

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Bibliografiske detaljer
Udgivet i:Cell Death Discov
Main Authors: Fang, Yili, Li, Fang, Qi, Chenyang, Mao, Xing, Wang, Feng, Zhao, Zhonghua, Chen, Jian-Kang, Zhang, Zhigang, Wu, Huijuan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7295815/
https://ncbi.nlm.nih.gov/pubmed/32566257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-0285-0
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