Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors

We report the synthesis and evaluation of a class of selective multitarget agents for the inhibition of HDAC6, HDAC8, and HDAC10. The concept for this study grew out of a structural analysis of the two selective inhibitors Tubastatin A (HDAC6/10) and PCI‐34051 (HDAC8), which we recognized share the...

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Bibliografski detalji
Izdano u:ChemMedChem
Glavni autori: Morgen, Michael, Steimbach, Raphael R., Géraldy, Magalie, Hellweg, Lars, Sehr, Peter, Ridinger, Johannes, Witt, Olaf, Oehme, Ina, Herbst‐Gervasoni, Corey J., Osko, Jeremy D., Porter, Nicholas J., Christianson, David W., Gunkel, Nikolas, Miller, Aubry K.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Full Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335359/
https://ncbi.nlm.nih.gov/pubmed/32348628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000149
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