Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors

We report the synthesis and evaluation of a class of selective multitarget agents for the inhibition of HDAC6, HDAC8, and HDAC10. The concept for this study grew out of a structural analysis of the two selective inhibitors Tubastatin A (HDAC6/10) and PCI‐34051 (HDAC8), which we recognized share the...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Morgen, Michael, Steimbach, Raphael R., Géraldy, Magalie, Hellweg, Lars, Sehr, Peter, Ridinger, Johannes, Witt, Olaf, Oehme, Ina, Herbst‐Gervasoni, Corey J., Osko, Jeremy D., Porter, Nicholas J., Christianson, David W., Gunkel, Nikolas, Miller, Aubry K.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335359/
https://ncbi.nlm.nih.gov/pubmed/32348628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000149
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