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Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors
We report the synthesis and evaluation of a class of selective multitarget agents for the inhibition of HDAC6, HDAC8, and HDAC10. The concept for this study grew out of a structural analysis of the two selective inhibitors Tubastatin A (HDAC6/10) and PCI‐34051 (HDAC8), which we recognized share the...
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| Опубликовано в: : | ChemMedChem |
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| Главные авторы: | , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
John Wiley and Sons Inc.
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7335359/ https://ncbi.nlm.nih.gov/pubmed/32348628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000149 |
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