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Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase
The cytosolic class IIb histone deacetylase HDAC10 is an emerging target for drug design. As an inducer of autophagy, its selective inhibition suppresses the autophagic response that otherwise attenuates the efficacy of cytotoxic cancer chemotherapy drugs. HDAC10 is a zinc-dependent polyamine deacet...
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| Опубликовано в: : | ACS Chem Biol |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7442746/ https://ncbi.nlm.nih.gov/pubmed/32659072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00362 |
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