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Binding of N(8)-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation

Eukaryotic histone deacetylase 10 (HDAC10) is a Zn(2+)-dependent hydrolase that exhibits catalytic specificity for the hydrolysis of the polyamine N(8)-acetylspermidine. The recently determined crystal structure of HDAC10 from Danio rerio (zebrafish) reveals a narrow active site cleft and a negative...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Herbst-Gervasoni, Corey, Christianson, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904438/
https://ncbi.nlm.nih.gov/pubmed/31746596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00906
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