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Binding of N(8)-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation
Eukaryotic histone deacetylase 10 (HDAC10) is a Zn(2+)-dependent hydrolase that exhibits catalytic specificity for the hydrolysis of the polyamine N(8)-acetylspermidine. The recently determined crystal structure of HDAC10 from Danio rerio (zebrafish) reveals a narrow active site cleft and a negative...
Gorde:
| Argitaratua izan da: | Biochemistry |
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| Egile Nagusiak: | , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2019
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6904438/ https://ncbi.nlm.nih.gov/pubmed/31746596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00906 |
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