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Structure of Prokaryotic Polyamine Deacetylase Reveals Evolutionary Functional Relationships with Eukaryotic Histone Deacetylases

Polyamines are a ubiquitous class of polycationic small molecules that can influence gene expression by binding to nucleic acids. Reversible polyamine acetylation regulates nucleic acid binding and is required for normal cell cycle progression and proliferation. Here, we report the structures of Myc...

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Bibliografiske detaljer
Main Authors: Lombardi, Patrick M., Angell, Heather D., Whittington, Douglas A., Flynn, Erin F., Rajashankar, Kanagalaghatta R., Christianson, David W.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074186/
https://ncbi.nlm.nih.gov/pubmed/21268586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101859k
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