Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors

We report the synthesis and evaluation of a class of selective multitarget agents for the inhibition of HDAC6, HDAC8, and HDAC10. The concept for this study grew out of a structural analysis of the two selective inhibitors Tubastatin A (HDAC6/10) and PCI‐34051 (HDAC8), which we recognized share the...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:ChemMedChem
Autors principals: Morgen, Michael, Steimbach, Raphael R., Géraldy, Magalie, Hellweg, Lars, Sehr, Peter, Ridinger, Johannes, Witt, Olaf, Oehme, Ina, Herbst‐Gervasoni, Corey J., Osko, Jeremy D., Porter, Nicholas J., Christianson, David W., Gunkel, Nikolas, Miller, Aubry K.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Full Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335359/
https://ncbi.nlm.nih.gov/pubmed/32348628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000149
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars