The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines

High histone deacetylase (HDAC) 8 and HDAC10 expression levels have been identified as predictors of exceptionally poor outcomes in neuroblastoma, the most common extracranial solid tumor in childhood. HDAC8 inhibition synergizes with retinoic acid treatment to induce neuroblast maturation in vitro...

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Foilsithe in:Arch Toxicol
Main Authors: Kolbinger, Fiona R., Koeneke, Emily, Ridinger, Johannes, Heimburg, Tino, Müller, Michael, Bayer, Theresa, Sippl, Wolfgang, Jung, Manfred, Gunkel, Nikolas, Miller, Aubry K., Westermann, Frank, Witt, Olaf, Oehme, Ina
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer Berlin Heidelberg 2018
Ábhair:
Genotoxicity and Carcinogenicity
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063332/
https://ncbi.nlm.nih.gov/pubmed/29947893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-018-2234-8
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