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Quantile normalization of single-cell RNA-seq read counts without unique molecular identifiers
Single-cell RNA-seq (scRNA-seq) profiles gene expression of individual cells. Unique molecular identifiers (UMIs) remove duplicates in read counts resulting from polymerase chain reaction, a major source of noise. For scRNA-seq data lacking UMIs, we propose quasi-UMIs: quantile normalization of read...
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| Udgivet i: | Genome Biol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7333325/ https://ncbi.nlm.nih.gov/pubmed/32620142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02078-0 |
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