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BUTTERFLY: addressing the pooled amplification paradox with unique molecular identifiers in single-cell RNA-seq
The incorporation of unique molecular identifiers (UMIs) in single-cell RNA-seq assays makes possible the identification of duplicated molecules, thereby facilitating the counting of distinct molecules from sequenced reads. However, we show that the naïve removal of duplicates can lead to a bias due...
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| Veröffentlicht in: | Genome Biol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8188791/ https://ncbi.nlm.nih.gov/pubmed/34103073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02386-z |
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