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Feature selection and dimension reduction for single-cell RNA-Seq based on a multinomial model
Single-cell RNA-Seq (scRNA-Seq) profiles gene expression of individual cells. Recent scRNA-Seq datasets have incorporated unique molecular identifiers (UMIs). Using negative controls, we show UMI counts follow multinomial sampling with no zero inflation. Current normalization procedures such as log...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Genome Biol |
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| Κύριοι συγγραφείς: | , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
BioMed Central
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6927135/ https://ncbi.nlm.nih.gov/pubmed/31870412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1861-6 |
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