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Catalytic, Enantioselective 1,2-Difluorination of Cinnamamides

We report the enantio- and diastereoselective synthesis of 1,2-difluorides via chiral aryl iodide-catalyzed difluorination of cinnamamides. The method uses HF-pyridine as a fluoride source and mCPBA as a stoichiometric oxidant to turn over catalyst, and affords compounds containing vicinal, fluoride...

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Xehetasun bibliografikoak
Argitaratua izan da:Org Lett
Egile Nagusiak: Haj, Moriana K., Banik, Steven M., Jacobsen, Eric N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7330813/
https://ncbi.nlm.nih.gov/pubmed/30963766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.9b00938
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