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Catalytic Enantioselective Synthesis of Difluorinated Alkyl Bromides

We report an iodoarene-catalyzed enantioselective synthesis of β,β-difluoroalkyl halide building blocks. The transformation involves an oxidative rearrangement of α-bromostyrenes, utilizing HF–pyridine as the fluoride source and m-CPBA as the stoichiometric oxidant. A catalyst decomposition pathway...

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Bibliografische gegevens
Gepubliceerd in:J Am Chem Soc
Hoofdauteurs: Levin, Mark D., Ovian, John M., Read, Jacquelyne A., Sigman, Matthew S., Jacobsen, Eric N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7537710/
https://ncbi.nlm.nih.gov/pubmed/32799536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c07043
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