Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms

Upregulated expression of efflux pumps, lpxC target mutations, LpxC protein overexpression, and mutations in fabG were previously shown to mediate single-step resistance to the LpxC inhibitor CHIR-090 in P. aeruginosa. Single-step selection experiments using three recently described LpxC inhibitors...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Jones, Adriana K., Caughlan, Ruth E., Woods, Angela L., Uehara, Kyoko, Xie, Lili, Barnes, S. Whitney, Walker, John R., Thompson, Katherine V., Ranjitkar, Srijan, Lee, Patrick S., Dean, Charles R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187589/
https://ncbi.nlm.nih.gov/pubmed/31658970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01490-19
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