Molecular Validation of LpxC as an Antibacterial Drug Target in Pseudomonas aeruginosa

LpxC [UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase] is a metalloamidase that catalyzes the first committed step in the biosynthesis of the lipid A component of lipopolysaccharide. A previous study (H. R. Onishi, B. A. Pelak, L. S. Gerckens, L. L. Silver, F. M. Kahan, M. H. Chen, A. A. Patchett,...

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Detaylı Bibliyografya
Asıl Yazarlar: Mdluli, Khisimuzi E., Witte, Pamela R., Kline, Toni, Barb, Adam W., Erwin, Alice L., Mansfield, Bryce E., McClerren, Amanda L., Pirrung, Michael C., Tumey, L. Nathan, Warrener, Paul, Raetz, Christian R. H., Stover, C. Kendall
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2006
Konular:
Mechanisms of Action: Physiological Effects
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479155/
https://ncbi.nlm.nih.gov/pubmed/16723580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00140-06
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