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Stucture of the LpxC deacetylase with a bound substrate-analog inhibitor
The zinc-dependent UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) catalyzes the first committed step in the biosynthesis of lipid A, the hydrophobic anchor of lipopolysaccharide (LPS) that constitutes the outermost monolayer of Gram- negative bacteria. As LpxC is crucial for the survival of Gra...
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| Publicado en: | Nat Struct Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6783277/ https://ncbi.nlm.nih.gov/pubmed/12833153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsb948 |
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