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Mechanistic Inferences from the Binding of Ligands to LpxC, a Metal-Dependent Deacetylase(,)

The metal-dependent deacetylase LpxC catalyzes the first committed step of lipid A biosynthesis in Gram-negative bacteria. Accordingly, LpxC is an attractive target for the development of inhibitors that may serve as potential new antibiotics for the treatment of Gram-negative bacterial infections....

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Main Authors: Gennadios, Heather A., Whittington, Douglas A., Li, Xuechen, Fierke, Carol A., Christianson, David W.
格式: Artigo
語言:Inglês
出版: 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2505344/
https://ncbi.nlm.nih.gov/pubmed/16800620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060823m
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