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Structures of Metal-Substituted Human Histone Deacetylase 8 Provide Mechanistic Inferences on Biological Function,
The metal-dependent histone deacetylases (HDACs) adopt an α/β protein fold first identified in rat liver arginase. Despite insignificant overall amino acid sequence identity, these enzymes share a strictly conserved metal-binding site with divergent metal specificity and stoichiometry. HDAC8, origin...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2895166/ https://ncbi.nlm.nih.gov/pubmed/20545365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1005046 |
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