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Structure of the Metal-Dependent Deacetylase LpxC from Yersinia enterocolitica Complexed with the Potent Inhibitor CHIR-090

The first committed step of lipid A biosynthesis is catalyzed by UDP-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase, a metal-dependent deacetylase also known as LpxC. Because lipid A is essential for bacterial viability, the inhibition of LpxC is an appealing therapeutic strategy for t...

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Main Authors: Cole, Kathryn E., Gattis, Samuel G., Angell, Heather D., Fierke, Carol A., Christianson, David W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070812/
https://ncbi.nlm.nih.gov/pubmed/21171638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101622a
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