Yüklüyor......

Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding

The UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase LpxC is an essential enzyme of lipid A biosynthesis in Gram-negative bacteria and a promising antibiotic target. CHIR-090, the most potent LpxC inhibitor discovered to date, displays two-step time-dependent inhibition and kills a wide ran...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Barb, Adam W., Jiang, Ling, Raetz, Christian R. H., Zhou, Pei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2007
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2141794/
https://ncbi.nlm.nih.gov/pubmed/18025458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709412104
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!