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Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding

The UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase LpxC is an essential enzyme of lipid A biosynthesis in Gram-negative bacteria and a promising antibiotic target. CHIR-090, the most potent LpxC inhibitor discovered to date, displays two-step time-dependent inhibition and kills a wide ran...

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Autori principali: Barb, Adam W., Jiang, Ling, Raetz, Christian R. H., Zhou, Pei
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2141794/
https://ncbi.nlm.nih.gov/pubmed/18025458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709412104
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