Mechanisms Decreasing In Vitro Susceptibility to the LpxC Inhibitor CHIR-090 in the Gram-Negative Pathogen Pseudomonas aeruginosa

Testing P. aeruginosa efflux pump mutants showed that the LpxC inhibitor CHIR-090 is a substrate for MexAB-OprM, MexCD-OprJ, and MexEF-OprN. Utilizing P. aeruginosa PAO1 with a chromosomal mexC::luxCDABE fusion, luminescent mutants arose on medium containing 4 μg/ml CHIR-090, indicating upregulation...

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Detalhes bibliográficos
Main Authors: Caughlan, Ruth E., Jones, Adriana K., DeLucia, Angela M., Woods, Angela L., Xie, Lili, Ma, Bing, Barnes, S. Whitney, Walker, John R., Sprague, Elizabeth R., Yang, Xia, Dean, Charles R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256010/
https://ncbi.nlm.nih.gov/pubmed/22024823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05417-11
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