Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms

Upregulated expression of efflux pumps, lpxC target mutations, LpxC protein overexpression, and mutations in fabG were previously shown to mediate single-step resistance to the LpxC inhibitor CHIR-090 in P. aeruginosa. Single-step selection experiments using three recently described LpxC inhibitors...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Jones, Adriana K., Caughlan, Ruth E., Woods, Angela L., Uehara, Kyoko, Xie, Lili, Barnes, S. Whitney, Walker, John R., Thompson, Katherine V., Ranjitkar, Srijan, Lee, Patrick S., Dean, Charles R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187589/
https://ncbi.nlm.nih.gov/pubmed/31658970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01490-19
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