Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms

Upregulated expression of efflux pumps, lpxC target mutations, LpxC protein overexpression, and mutations in fabG were previously shown to mediate single-step resistance to the LpxC inhibitor CHIR-090 in P. aeruginosa. Single-step selection experiments using three recently described LpxC inhibitors...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Jones, Adriana K., Caughlan, Ruth E., Woods, Angela L., Uehara, Kyoko, Xie, Lili, Barnes, S. Whitney, Walker, John R., Thompson, Katherine V., Ranjitkar, Srijan, Lee, Patrick S., Dean, Charles R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2019
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187589/
https://ncbi.nlm.nih.gov/pubmed/31658970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01490-19
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