Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis

Tight coordination of inner and outer membrane biosynthesis is very important in Gram-negative bacteria. Biosynthesis of the lipid A moiety of lipopolysaccharide, which comprises the outer leaflet of the outer membrane has garnered interest for Gram-negative antibacterial discovery. In particular, s...

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Detalles Bibliográficos
Publicado en:mSphere
Main Authors: Mostafavi, Mina, Wang, Lisha, Xie, Lili, Takeoka, Kenneth T., Richie, Daryl L., Casey, Fergal, Ruzin, Alexey, Sawyer, William S., Rath, Christopher M., Wei, Jun-Rong, Dean, Charles R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6211225/
https://ncbi.nlm.nih.gov/pubmed/30381354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00508-18
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