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Mutants Resistant to LpxC Inhibitors by Rebalancing Cellular Homeostasis

LpxC, the deacetylase that catalyzes the second and committed step of lipid A biosynthesis in Escherichia coli, is an essential enzyme in virtually all Gram-negative bacteria and is one of the most promising antibiotic targets for treatment of multidrug-resistant Gram-negative infections. Despite th...

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Detalhes bibliográficos
Main Authors: Zeng, Daina, Zhao, Jinshi, Chung, Hak Suk, Guan, Ziqiang, Raetz, Christian R. H., Zhou, Pei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581379/
https://ncbi.nlm.nih.gov/pubmed/23316051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.447607
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