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Mutants Resistant to LpxC Inhibitors by Rebalancing Cellular Homeostasis
LpxC, the deacetylase that catalyzes the second and committed step of lipid A biosynthesis in Escherichia coli, is an essential enzyme in virtually all Gram-negative bacteria and is one of the most promising antibiotic targets for treatment of multidrug-resistant Gram-negative infections. Despite th...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3581379/ https://ncbi.nlm.nih.gov/pubmed/23316051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.447607 |
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