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Syntheses, Structures and Antibiotic Activities of LpxC Inhibitors Based on the Diacetylene Scaffold

Compounds inhibiting LpxC in the lipid A biosynthetic pathway are promising leads for novel antibiotics against multidrug-resistant Gram-negative pathogens. We report the syntheses and structural and biochemical characterizations of LpxC inhibitors based on a diphenyl-diacetylene (1,4-diphenyl-1,3-b...

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Detalhes bibliográficos
Main Authors: Liang, Xiaofei, Lee, Chul-Jin, Chen, Xin, Chung, Hak Suk, Zeng, Daina, Raetz, Christian R. H., Li, Yaoxian, Zhou, Pei, Toone, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035996/
https://ncbi.nlm.nih.gov/pubmed/21194954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.12.017
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