High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors

OBJECTIVES: Inhibitors of uridine diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC, which catalyses the first, irreversible step in lipid A biosynthesis) are a promising new class of antibiotics against Gram-negative bacteria. The objectives of the present study were to:...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Titecat, Marie, Liang, Xiaofei, Lee, Chul-Jin, Charlet, Audrey, Hocquet, Didier, Lambert, Thierry, Pagès, Jean-Marie, Courcol, René, Sebbane, Florent, Toone, Eric J., Zhou, Pei, Lemaitre, Nadine
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5031916/
https://ncbi.nlm.nih.gov/pubmed/27330072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw210
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