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Structural Basis of the Promiscuous Inhibitor Susceptibility of E. coli LpxC
The LpxC enzyme in the lipid A biosynthetic pathway is one of the most promising and clinically unexploited antibiotic targets for treatment of multidrug-resistant Gram-negative infections. Progress in medicinal chemistry has led to the discovery of potent LpxC inhibitors with a variety of chemical...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3947053/ https://ncbi.nlm.nih.gov/pubmed/24117400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400067g |
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