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A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058

The difluoromethyl-allo-threonyl hydroxamate-based compound LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) in Gram-negative bacteria. A scalable synthesis of this compound is described. The key step in the synthetic sequence is a transition met...

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Detalles Bibliográficos
Publicado en:J Org Chem
Autores principales: Liang, Xiaofei, Gopalaswamy, Ramesh, Navas, Frank, Toone, Eric J., Zhou, Pei
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5164921/
https://ncbi.nlm.nih.gov/pubmed/27128325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.6b00589
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