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Synthesis, structure and antibiotic activity of aryl-substituted LpxC inhibitors
The zinc-dependent deacetylase LpxC catalyzes the committed step of lipid A biosynthesis in Gram-negative bacteria and is a validated target for development of novel antibiotics to combat multidrug-resistant Gram-negative infections. Many potent LpxC inhibitors contain an essential threonyl-hydroxam...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3941642/ https://ncbi.nlm.nih.gov/pubmed/23914798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4007774 |
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